Anti-CD50

CD50 (ICAM-3) that is expressed in virtually all leukocytes, belongs to the family of the intercellular adhesion molecules. It is also shown to be important part in immune response initiation. CD50 is a useful marker for non-hodgkin's lymphoma and it is expressed in almost all the tumors with tendency to be lost in high grade lymphomas. Control: Appendix, tonsil. Protein function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha- L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). [The UniProt Consortium]