Anti-CD5 Monoclonal Antibody (Clone:L17F12)-APC Conjugated

Anti-CD5 Monoclonal Antibody (Clone:L17F12)-APC Conjugated
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-30-1804-100 100 tests -

3 - 11 business days*

713.00€
 
CD5 antigen (T1, 67 kDa) is a human cell surface T-lymphocyte single-chain transmembrane... more
Product information "Anti-CD5 Monoclonal Antibody (Clone:L17F12)-APC Conjugated"
CD5 antigen (T1, 67 kDa) is a human cell surface T-lymphocyte single-chain transmembrane glycoprotein. CD5 is expressed on all mature T-lymphocytes, most of thymocytes, subset of B-lymphocytes and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains.The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 crosslinking induces extracellular Ca++ mobilization, tyrosine phosphorylation of intracellular proteins and DAG production. Preliminary evidence shows protein associations with ZAP-70, p56lck, p59fyn, PC-PLC, etc. CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD5 is the phenotypic marker of a B cell subpopulation involved in the production of autoreactive antibodies.Disease relevance: CD5 is a phenotypic marker for some B cell lymphoproliferative disorders (B-CLL, Hairy cell leukemia, etc.). The CD5+ popuation is expanded in some autoimmune disorders (Rheumatoid Arthritis, etc.). Herpes virus infections induce loss of CD5 expression in the expanded CD8+ human T cells. Protein function: May act as a receptor in regulating T-cell proliferation. [The UniProt Consortium]
Keywords: Anti-CD5, Anti-LEU1, Anti-Lymphocyte antigen T1/Leu-1, Anti-T-cell surface glycoprotein CD5, Anti-CD5 Monoclonal Antibody (Clone:L17F12)-APC Conjugated
Supplier: Abeomics
Supplier-Nr: 30-1804

Properties

Application: FC, IP, WB, ICC
Antibody Type: Monoclonal
Clone: L17F12
Conjugate: APC
Host: Mouse
Species reactivity: human
Immunogen: Human acute lymphoblastic leukemia (ALL) T cells

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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