Anti-CD49d (APC), clone PS/2

Anti-CD49d (APC), clone PS/2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
G-AGIM0476.100 100 µl -

9 - 20 business days*

Protein function: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for... more
Product information "Anti-CD49d (APC), clone PS/2"
Protein function: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). [The UniProt Consortium]
Keywords: Anti-ITGA4, Anti-CD49D, Anti-CD49d, Anti-Integrin alpha-4, Anti-Integrin alpha-IV, Anti-VLA-4 subunit alpha, Anti-CD49 antigen-like family member D, CD49d monoclonal antibody (APC) (AGIM0476)
Supplier: Assay Genie
Supplier-Nr: AGIM0476


Application: FC
Antibody Type: Monoclonal
Clone: PS/2
Conjugate: APC
Host: Rat
Reactivity: Human

Handling & Safety

Storage: vT
Shipping: +4°C (International: +4°C)
Our products are for laboratory research use only: Not for administration to humans!
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