Anti-CD46 (Membrane cofactor protein, MCP)

Anti-CD46 (Membrane cofactor protein, MCP)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
C2401-02C.100 100 µg - -

3 - 19 business days*

727.00€
 
CD46, also designated membrane cofactor protein, is a 45-70kD protein with genetic and... more
Product information "Anti-CD46 (Membrane cofactor protein, MCP)"
CD46, also designated membrane cofactor protein, is a 45-70kD protein with genetic and tissue-specific heterogeneity. It is expressed on every cell and tissue, with the exception of erythrocytes. CD46 serves to down-regulate the activation of complement on host tissue. It performs this function by serving as a cofactor which binds to C3b and C4b. This binding is permitted by factor I, a serine protease of plasma, to degrade C3b and C4b and serves to protect the host cell against autologous attack. It also serves as a receptor for measles virus. Four isoforms of CD46 predominate and arise by alternative splicing of a single CD46 gene. The isoforms differ in the length. CD46 cDNA encodes a signal sequence followed by four complement control protein domains (also called short consensus repeats (SCR)). Applications: Suitable for use in ELISA, Flow Cytometry, Immunohistochemistry (frozen), Immunoprecipitation and Western Blot. Also suitable for inhibition of biological activity. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:10, Western Blot: 1:10 (non-reduced sample treatment and SDS-PAGE), Immunohistochemistry: 1:10, Immunoprecipitation: 25ug antibody and 25ug Protein G-Sepharose were used to immunoprecipitate 10e7 cells., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Supplier: United States Biological
Supplier-Nr: C2401-02C

Properties

Application: FC, IHC, IP, WB
Antibody Type: Monoclonal
Clone: 9G152
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Human CD46.
Format: Purified

Database Information

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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