Anti-CD45RO (T-cell marker), clone SPM125

Anti-CD45RO (T-cell marker), clone SPM125
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V2420IHC-7ML 7 ml - -

3 - 10 business days*

752.00€
 
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide, *For IHC use only*.... more
Product information "Anti-CD45RO (T-cell marker), clone SPM125"
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide, *For IHC use only*. Recognizes a 180-185kDa protein, identified as isoform of leukocyte common antigen (CD45RO). This antibody reacts with mature activated T-cells, most thymocytes, and a sub-population of resting T-cells within both CD4 and CD8 subsets. It shows no reactivity with normal B or natural killer cells, but reacts with granulocytes and monocytes. Reportedly, it is useful to identify T-cell lymphomas and leukemias. It rarely stains NK cells or B-cell lymphomas. Protein function: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. [The UniProt Consortium]
Keywords: Anti-T200, Anti-CD45, Anti-L-CA, EC=3.1.3.48, Anti-Leukocyte common antigen, Anti-Receptor-type tyrosine-protein phosphatase C, CD45RO Antibody (T-cell marker)
Supplier: NSJ Bioreagents
Supplier-Nr: V2420IHC

Properties

Application: IHC (paraffin)
Antibody Type: Monoclonal
Clone: SPM125
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: Cultured human T-cells from an IL-2-dependent T-cell line (CA1)
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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