Anti-CD45RO (human), Unconjugated Clone UCHL1 [Mouse]

Specificity: The antibody UCHL1 recognizes CD45R0, a 180 kDa low molecular weight isoform of the leukocyte common antigen (LCA). The antigen is expressed on a subset of memory/activated T cells and on cortical thymocytes., Format: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4, Working Dilution: Use 10 µl of the suggested working dilution to label 106 cells in 100 µl., Storage: Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label., Application Notes: Immunoflourescent staining, IP, IHC paraffin and frozen Protein function: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. [The UniProt Consortium]