Anti-CD45 / LCA Monoclonal Antibody (Clone:MEM-28)-FITC Conjugated

Anti-CD45 / LCA Monoclonal Antibody (Clone:MEM-28)-FITC Conjugated
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-30-1950-100 100 tests -

3 - 11 business days*

653.00€
 
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously... more
Product information "Anti-CD45 / LCA Monoclonal Antibody (Clone:MEM-28)-FITC Conjugated"
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing, these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. Protein function: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. [The UniProt Consortium]
Keywords: Anti-T200, Anti-CD45, Anti-L-CA, EC=3.1.3.48, Anti-Leukocyte common antigen, Anti-Receptor-type tyrosine-protein phosphatase C, Anti-CD45 / LCA Monoclonal Antibody (Clone:MEM-28)-FITC Conjugated
Supplier: Abeomics
Supplier-Nr: 30-1950

Properties

Application: FC, IP, WB, IHC, ICC
Antibody Type: Monoclonal
Clone: MEM-28
Conjugate: FITC
Host: Mouse
Species reactivity: human
Immunogen: Human thymocytes and T lymphocytes.

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-CD45 / LCA Monoclonal Antibody (Clone:MEM-28)-FITC Conjugated"
Write a review
or to review a product.
Viewed