Anti-CD44v4/5, clone 3D2

Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V8250-20UG 20 µg - -

3 - 10 business days*

332.00€
NSJ-V8250-100UG 100 µg - -

3 - 10 business days*

752.00€
 
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. This antibody recognizes an... more
Product information "Anti-CD44v4/5, clone 3D2"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. This antibody recognizes an epitope encoded by exon v9 on the variant portion of human CD44. The CD44 molecule belongs to a family of cellular adhesion molecules found on a wide range of normal and malignant cells in epithelial, mesothelial and hemopoiesis tissues. CD44 is a single gene with 20 exons, of which 10 are normally expressed to encode the basic CD44 (H-CAM) molecule. The additional 10 exons (v1 to v10) are only expressed by alternative splicing of the nuclear RNA.The expression of specific cell adhesion molecule CD44 splice variants has been reported to be associated with metastasis in certain human malignancies. Protein function: Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640). [The UniProt Consortium]
Keywords: Anti-LHR, Anti-CD44, Anti-PGP-I, Anti-PGP-1, Anti-CDw44, Anti-Epican, Anti-HUTCH-I, Anti-ECMR-III, Anti-CD44 antigen, Anti-Hermes antigen, Anti-Hyaluronate receptor, Anti-Phagocytic glycoprotein I, Anti-Phagocytic glycoprotein 1, CD44v4/5 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V8250

Properties

Application: FC, WB, IHC (paraffin)
Antibody Type: Monoclonal
Clone: 3D2
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: A recombinant human full-length CD44v3-10 protein
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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