Anti-CD44 / HCAM, clone SPM544

Anti-CD44 / HCAM, clone SPM544
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V9105IHC-7ML 7 ml - -

3 - 10 business days*

752.00€
 
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide, *For IHC use only*.... more
Product information "Anti-CD44 / HCAM, clone SPM544"
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide, *For IHC use only*. Recognizes a cell surface glycoprotein of 80-95kDa (CD44) on lymphocytes, monocytes, and granulocytes. Its epitope is resistant to digestion by trypsin and chymotrypsin. The CD44 family of glycoproteins exists in a number of variant isoforms, the most common being the standard 85-95kDa or hematopoietic variant (CD44s). Higher molecular weight isoforms are described in epithelial cells (CD44v), which are believed to function in intercellular adhesion and stromal binding. CD44 immunostaining is commonly used for the discrimination of urothelial transitional cell carcinoma in-situ from non-neoplastic changes in the urothelium. Protein function: Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640). [The UniProt Consortium]
Keywords: Anti-LHR, Anti-CD44, Anti-PGP-I, Anti-PGP-1, Anti-CDw44, Anti-Epican, Anti-HUTCH-I, Anti-ECMR-III, Anti-CD44 antigen, Anti-Hermes antigen, Anti-Hyaluronate receptor, Anti-Phagocytic glycoprotein I, Anti-Phagocytic glycoprotein 1, CD44 Antibody / HCAM
Supplier: NSJ Bioreagents
Supplier-Nr: V9105IHC

Properties

Application: IHC (paraffin)
Antibody Type: Monoclonal
Clone: SPM544
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: Stimulated human leukocytes
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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