Anti-CD44 (CD44 Antigen, Extracellular Matrix Receptor III, ECMR-III, GP90 Lymphocyte Homing/Adhesio

Anti-CD44 (CD44 Antigen, Extracellular Matrix Receptor III, ECMR-III, GP90 Lymphocyte Homing/Adhesio
Item number Size Datasheet Manual SDS Delivery time Quantity Price
C2398-70A.100 100 tests - -

3 - 19 business days*

595.00€
 
CD44 is a ubiquitously expressed protein that is the major receptor for hyaluronan and exerts... more
Product information "Anti-CD44 (CD44 Antigen, Extracellular Matrix Receptor III, ECMR-III, GP90 Lymphocyte Homing/Adhesio"
CD44 is a ubiquitously expressed protein that is the major receptor for hyaluronan and exerts control over cell growth and migration. The many reported functions of CD44 fall within three categories. First, CD44 binds hyaluronan and other ligands within the extracellular matrix and can function as a "platform" for growth factors and metalloproteinases. Second, CD44 acts as a co-receptor, which can modify the activity of receptors including MET and the ErbB family of tyrosine kinases. Third, the CD44 intracellular domain links the plasma membrane to the actin cytoskeleton via the ERM proteins, ezrin, radixin and moesin. CD44 can be synthesized in a soluble form or may be cleaved at multiple sites by either membrane-type matrix metalloproteinases, or ADAM proteases to produce soluble ectodomains. The cellular portion may then undergo gamma secretase-dependent intramembrane cleavage to form an AB-like transmembrane portion and a cytoplasmic signaling portion that affects gene expression. These cleavage events are thought to promote metastasis by enhancing tumor cell motility and growth. Within the N-terminal invariant portion of the ECD (aa23-222), mouse CD44 shares 92%, 77%, 77%, 79%, and 71% aa sequence identity with rat, human, equine, canine, and bovine CD44, respectively. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilutions: Flow Cytometry: 10ul labels up to 1x10e6 cells using rat splenocytes, Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Keywords: Anti-Cd44, Anti-CD44, Anti-PGP-1, Anti-PGP-I, Anti-HUTCH-I, Anti-ECMR-III, Anti-CD44 antigen, Anti-Hermes antigen, Anti-Hyaluronate receptor, Anti-Phagocytic glycoprotein 1, Anti-Phagocytic glycoprotein I, Anti-Extracellular matrix receptor III
Supplier: United States Biological
Supplier-Nr: C2398-70A

Properties

Application: FC
Antibody Type: Monoclonal
Clone: 12K35
Conjugate: APC
Host: Mouse
Reactivity: Rat
Immunogen: Recombinant corresponding to rat CD44 expressed in NSO cell line.
Format: Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow. more
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-CD44 (CD44 Antigen, Extracellular Matrix Receptor III, ECMR-III, GP90 Lymphocyte Homing/Adhesio"
Write a review
or to review a product.
Viewed