Anti-CD43

Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-R31521 100 µg - -

3 - 10 business days*

755.00€
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. CD43, also known as leukosialin or... more
Product information "Anti-CD43"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. CD43, also known as leukosialin or sialophorin, is a transmembrane cell surface protein that in humans is encoded by the SPN gene. It is mapped to 16p11.2. It is a major sialoglycoprotein on the surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes, which is important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation. Expression of CD43 is deficient and/or defective in the X-chromosome-linked immunodeficiency disorder Wiscott-Aldrich syndrome, suggesting that CD43 have a role in T-cell activation. T-cell activation requires the removal of CD43 from the immunologic synapse to allow efficient engagement of the TCR with molecules on the APC. Protein function: One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1. During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response. [The UniProt Consortium]
Keywords: Anti-SPN, Anti-CD43, Anti-GALGP, Anti-Sialophorin, Anti-Leukosialin, Anti-Galactoglycoprotein, Anti-Leukocyte sialoglycoprotein, CD43 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: R31521

Properties

Application: WB, IHC (paraffin), ICC, FC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: Human partial recombinant protein (AA 272-400)
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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