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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay32324-100 | 100 µl | - |
6 - 10 business days* |
480.00€
|
CD38, also known as ADP-ribosyl cyclase 1, is a single-chain type II transmembrane glycoprotein... more
Product information "Anti-CD38 Rabbit Monoclonal"
CD38, also known as ADP-ribosyl cyclase 1, is a single-chain type II transmembrane glycoprotein with enzymatic activity and cell surface receptor functions that has roles in calcium signaling and immunomodulation. It is composed of a C-terminal catalytic domain, which can be orientated towards the extracellular or intracellular environment, a transmembrane segment, and a short N-terminal cytoplasmic tail, which interacts with the tyrosine kinase Lck. CD38 expression is induced by cytokine, interferon, or endotoxin stimulation in a variety of immune cells, including T cells, B cells, granulocytes, and natural killer (NK) cells, as well as malignant plasma cells, and predominantly localizes to lipid rafts. It is also found in the nucleus and mitochondrial membrane, as well as in the cytoplasm. CD38 regulates calcium signaling by catalyzing the formation of the intracellular calcium mobilizing messengers cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate (NAADP). It is a receptor for CD31, an adhesion molecule expressed by endothelial cells, and associates with a variety of signaling complexes, such as CD3/T cell receptor and CD19/CD21/B cell receptor complexes. CD38 protein expression is increased on plasma cells isolated from patients with multiple myeloma. Cayman's CD38 Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.Synonyms: ADP-ribosyl Cyclase 1. Immunogen: Peptide corresponding to residues near the C-terminus of human CD38. Clone Designation: RM388. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC, WB. Cross Reactivity: (+) CD38.
Keywords: | ADP-ribosyl Cyclase 1 |
Supplier: | Cayman Chemical |
Supplier-Nr: | 32324 |
Properties
Application: | IHC, WB |
Antibody Type: | Monoclonal |
Clone: | RM388 |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Peptide corresponding to residues near the C-terminus of human CD38 |
Format: | Purified |
Database Information
KEGG ID : | K01242 | Matching products |
UniProt ID : | P28907 | Matching products |
Gene ID | GeneID 952 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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