Anti-CD36 FITC (Clone JC63.1)

Anti-CD36 FITC (Clone JC63.1)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10009870-1 1 each -

6 - 10 business days*

472.00€
 
CD36, also known as scavenger receptor B2 or fatty acid translocase, is a transmembrane... more
Product information "Anti-CD36 FITC (Clone JC63.1)"
CD36, also known as scavenger receptor B2 or fatty acid translocase, is a transmembrane glycoprotein that has roles in fatty acid uptake and lipid metabolism and signaling. It is composed of N- and C-terminal cytoplasmic tails, two transmembrane domains, and an extracellular loop that binds to a variety of lipid ligands, including long-chain fatty acids, oxidized LDL, and oxidized phospholipids, and protein ligands, such as thrombospondin (TSP-1), and is subject to post-translational modifications. CD36 is expressed by a variety of cells, including hematopoietic cells such as platelets, monocytes, and macrophages, as well as adipocytes, enterocytes, cardiac and skeletal myocytes, and endothelial and epithelial cells. It also exists as a soluble form, sCD36, which is produced via plasma proteases. CD36 expression is regulated by several transcription factors, including peroxisome proliferator-activated receptor (PPAR), STAT3, and hypoxia-inducible factor-1alpha (HIF-1alpha), in a tissue-dependent manner. It is localized to the plasma membrane and within endosomes, the endoplasmic reticulum, and mitochondria, and is translocated between these compartments in response to various stimuli, including insulin-induced PI3K signaling and muscle contraction-induced AMPK signaling, to regulate fatty acid uptake. It has additional roles in the phagocytosis of apoptotic cells and P. falciparum-infected red blood cells (RBCs), angiogenesis, thrombosis, inflammation, and atherosclerosis, as well as cancer metastasis. Cayman's Scavenger Receptor B2/CD36 Monoclonal FITC Antibody (Clone JC63.1) can be used for flow cytometry (FC) and immunofluorescence (IF) applications.Synonyms: GPIIIb, GPIV, Platelet Glycoprotein 4, Fatty Acid Translocase, PAS IV, Platelet Collagen Receptor, Thrombospondin Receptor. Immunogen: recombinant adenovirus expressing full-length mouse CD36{9310}. Clone Designation: JC63.1. Formulation: (Request formulation change), 100 µg of fluorescein-labeled purified monoclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol, 0.1% BSA, and 0.02% sodium chloride. Host: CD36 null mouse. Isotype: IgA. Applications: FC, IF. UniProt Accession #: Q08857. Origin: Animal/Mouse.
Keywords: Anti-Cd36, Anti-GPIV, Anti-CD36, Anti-GPIV, Anti-CD36, Anti-PAS-4, Anti-PAS-4, Anti-GPIIIB, Anti-PAS IV, Anti-GPIIIB, Anti-PAS IV, Anti-Glycoprotein IIIb, Anti-Glycoprotein IIIb, Anti-Platelet glycoprotein 4, Anti-Platelet glycoprotein 4, Anti-Platelet gl
Supplier: Cayman Chemical
Supplier-Nr: 10009870

Properties

Application: FC, IF
Antibody Type: Monoclonal
Clone: JC63.1
Conjugate: FITC
Host: Mouse
Species reactivity: mouse
Immunogen: recombinant adenovirus expressing full-length mouse CD36{9310}
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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