Anti-CD34, clone ICO-115

Anti-CD34, clone ICO-115
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V2065CF488-100T 100 tests - -

3 - 10 business days*

752.00€
 
500 ul at 0.1 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. This antibody recognizes... more
Product information "Anti-CD34, clone ICO-115"
500 ul at 0.1 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. This antibody recognizes a carbohydrate epitope on a single chain, transmembrane, heavily glycosylated protein of 90-120kDa, which is identified as CD34 (VI international workshop on human differentiation antigens). Its expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, it is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. CD34 expression is also found in vascular endothelium. Additionally, it appears that proliferating endothelial cells overexpress this molecule than the non-proliferating endothelial cells. Anti-CD34 labels 85% of angiosarcoma and Kaposi's sarcoma, but shows low specificity. Protein function: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. [The UniProt Consortium]
Keywords: Anti-CD34, Anti-Hematopoietic progenitor cell antigen CD34, CD34 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V2065CF488

Properties

Application: FC
Antibody Type: Monoclonal
Clone: ICO-115
Conjugate: No
Host: Mouse
Species reactivity: human, rat
Immunogen: Blast cells from a chronic myeloid leukemia patient
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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