Anti-CD32 (Fc Gamma RIIa) Monoclonal Antibody (Clone: 8.7)

Anti-CD32 (Fc Gamma RIIa) Monoclonal Antibody (Clone: 8.7)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-36-2282-20 20 µg -

3 - 11 business days*

375.00€
ABE-36-2282-100 100 µg -

3 - 11 business days*

853.00€
 
This MAb reacts with a CD32 (FcgRII) epitope distinct from that defined by MAb 8.26 and the... more
Product information "Anti-CD32 (Fc Gamma RIIa) Monoclonal Antibody (Clone: 8.7)"
This MAb reacts with a CD32 (FcgRII) epitope distinct from that defined by MAb 8.26 and the epitope overlaps with that of MAb 7.30 (cluster 4). It displays a stronger reaction with Daudi than with U937 cells. The epitope is located in domain 2 of FcgRIIa. Its Fab'2 fragments block immune complex binding. CD32 (FcRII) is a type 1 transmembrane glycoprotein that mediates several functions including phagocytosis, cytotoxicity, and immunomodulation as well as platelet aggregation. Three genes (A, B, and C) encode CD32 and at least 6 isoforms are generated via alternative mRNA splicing, i.e., IIa1, IIa2, IIb1, IIb2, IIb3 and IIc. Monocytes/macrophages, placental trophoblasts and endothelial cells express all isoforms. In addition, the IIb isoform is expressed by B cells, and the IIa isoform by platelets, granulocytes and, weakly, by B cells. NK cells and neutrophils express Isoform IIc. CD32 binds weakly to the Fc region of monomeric IgG but more strongly to IgG aggregates and immune complexes. Protein function: Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens. [The UniProt Consortium]
Keywords: Anti-CD32, Anti-CDw32, Anti-FCGR2A, Anti-FcRII-a, Anti-Fc-gamma-RIIa, Anti-Fc-gamma RII-a, Anti-IgG Fc receptor II-a, Anti-Low affinity immunoglobulin gamma Fc region receptor II-a, Anti-CD32 (Fc Gamma RIIa) Monoclonal Antibody (Clone: 8.7)
Supplier: Abeomics
Supplier-Nr: 36-2282

Properties

Application: FC, IF
Antibody Type: Monoclonal
Clone: 8.7
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: K562 and FcgRII+L cells

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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