Anti-CD20, CT (MS4A1, B1, S7, Bp35, CD20, MS4A2, LEU-16, MGC3969, membrane-spanning 4-domains, subfa

Anti-CD20, CT (MS4A1, B1, S7, Bp35, CD20, MS4A2, LEU-16, MGC3969, membrane-spanning 4-domains, subfa
Item number Size Datasheet Manual SDS Delivery time Quantity Price
C2270-05H.100 100 µg - -

3 - 19 business days*

675.00€
 
CD20 is a non-glycosylated phosphoprotein expressed on the surface of all mature B-cells.... more
Product information "Anti-CD20, CT (MS4A1, B1, S7, Bp35, CD20, MS4A2, LEU-16, MGC3969, membrane-spanning 4-domains, subfa"
CD20 is a non-glycosylated phosphoprotein expressed on the surface of all mature B-cells. Membrane-spanning 4-domains, subfamily A, member 1, also known as MS4A1, is a human gene. This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. The protein has no known natural ligand and its function is unclear. It is suspected that it acts as a calcium channel in the cell membrane. CD20 is expressed on all stages of B cell development except the first and last, it is present from pre-pre B cells through memory cells, but not on either pro-B cells or plasma cells. It is found on B-cell lymphomas, hairy cell leukemia, and B-cell chronic lymphocytic leukemia. It is also found on skin/melanoma cancer stem cells. CD20 is the target of the monoclonal antibodies rituximab, Ibritumomab tiuxetan, and tositumomab, which are all active agents in the treatment of all B cell lymphomas and leukemias. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommneded Dilution: Peptide ELISA: 1:8000, Western Blot: 3-5ug/ml. Band seen at ~37kD in Daudi cell lysates. Overnight incubation is recommended. , Immunohistochemistry: 2-5ug/ml. In paraffin embedded human spleen shows strong membranous staining in the follicles formed by B-cells. , Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-B-lymphocyte antigen CD20, Anti-B-lymphocyte surface antigen B1, Anti-Leukocyte surface antigen Leu-16, Anti-Membrane-spanning 4-domains subfamily A member 1
Supplier: United States Biological
Supplier-Nr: C2270-05H

Properties

Application: ELISA, IHC, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Goat
Species reactivity: human
Immunogen: C-QDQESSPIENDSSP, C Terminus
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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