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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
MON-MON1019-1 | 1 ml | - | - |
Request delivery time estimate |
174.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
MON1019 is an alpha chain integrin that is expressed as heterodimer non-covalently associated... more
Product information "Anti-CD11b/CR3, clone BEAR-1 (Monoclonal) [Mouse]"
MON1019 is an alpha chain integrin that is expressed as heterodimer non-covalently associated with CD18. CD11b is also designated as CR3, Mac-1, Mo-1 in integrin alphaM subunit and has a molecular weight of 165-170 kDa. The protein mediates PMN and monocytes adherence to endothelium and subsequently PMN extravasation to sites of inflammation. CD11b/CD18 interacts with both matrix and cell surface proteins including the complement component iC3b, extracellular matrix proteins and the third extracellular domain of CD54. CD11b is expressed on human NK-cells, monocytes, granulocytes, T-cells, B-cells and dendritic cells. After activation the expression is upregulated. Bear-1 reacts with the CD11b alpha chain of the CD11b/CD18 (p165, 95) integrin heterodimer complex. Protein function: Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PubMed:9558116, PubMed:20008295). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development. Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development. [The UniProt Consortium]
Keywords: | Anti-CD11b, Anti-ITGAM, Anti-CD11B, Anti-CR-3 alpha chain, Anti-Integrin alpha-M, Anti-Neutrophil adherence receptor, Anti-Leukocyte adhesion receptor MO1, Anti-CD11 antigen-like family member B, Anti-Cell surface glycoprotein MAC-1 subunit alpha, Mouse a |
Supplier: | MONOSAN |
Supplier-Nr: | MON1019 |
Properties
Application: | FC, IHC, IP |
Antibody Type: | Monoclonal |
Clone: | BEAR-1 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Database Information
KEGG ID : | K06461 | Matching products |
UniProt ID : | P11215 | Matching products |
Gene ID | GeneID 3684 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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