Anti-CD105 (Endoglin)

Anti-CD105 (Endoglin)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
C2446-53.100 100 µl - -

3 - 19 business days*

Endoglin (ENG, CD105) is an auxiliary receptor for the TGF-beta receptor complex, functioning in... more
Product information "Anti-CD105 (Endoglin)"
Endoglin (ENG, CD105) is an auxiliary receptor for the TGF-beta receptor complex, functioning in related signaling pathways (1,2). Endoglin is a transmembrane protein that exists as a disulfide-linked homodimer. It is mainly expressed in vascular and connective tissues and in endothelial and stromal cells. Upregulated endoglin expression has been reported in wound healing, tumor vascularization, inflammatory tissues and in developing embryos (1-4). Mutations in endoglin have been found to be a causal factor of hereditary hemorrhagic telangiectasia (HHT), a disease characterized by malformation of vascular structure (5,6). The importance of this protein for normal and tumor vascular function makes it a good marker for endothelial cell proliferation as well as a potential therapeutic target in cancer (4-6). , Application: Suitable for use in ELISA and Western Blot. Other applications have not been tested. Recommended Dilutions: Western Blot: 1:1000, incubate membrane with diluted antibody in TBS, 5% BSA, 0.1% Tween-20 at 4°C with gentle shaking, overnight., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-ENG
Supplier: United States Biological
Supplier-Nr: C2446-53


Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Mouse
Immunogen: Synthetic peptide (KLH- coupled) corresponding to residues surrounding Pro430 of mouse endoglin.
Purity: Purified by peptide affinity chromatography.
Format: Affinity Purified

Handling & Safety

Storage: -20°C (-20°C Glycerol)
Shipping: +4°C (International: +4°C)
Our products are for laboratory research use only: Not for administration to humans!
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