Anti-CBL-C, NT (Signal Transduction Protein CBL-C, SH3-binding Protein CBL-C, SH3-binding Protein CB

Anti-CBL-C, NT (Signal Transduction Protein CBL-C, SH3-binding Protein CBL-C, SH3-binding Protein CB
Item number Size Datasheet Manual SDS Delivery time Quantity Price
C0013-34-PE.200 200 µl - -

4 - 22 business days

696.00€
 
Protein function: Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific... more
Product information "Anti-CBL-C, NT (Signal Transduction Protein CBL-C, SH3-binding Protein CBL-C, SH3-binding Protein CB"
Protein function: Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction, upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation, CD2AP converts it from an inhibitor to a promoter of RET degradation, the function limits the potency of GDNF on neuronal survival. [The UniProt Consortium]
Keywords: Anti-CBL3, Anti-CBLC, EC=6.3.2.-, Anti-RING finger protein 57, Anti-SH3-binding protein CBL-C, Anti-SH3-binding protein CBL-3, Anti-Signal transduction protein CBL-C, Anti-E3 ubiquitin-protein ligase CBL-C
Supplier-Nr: C0013-34-PE

Properties

Application: FLISA, IHC, WB
Antibody Type: Polyclonal
Host: Rabbit
Reactivity: Human
Immunogen: Synthetic peptide selected from the N-terminal region of human Cbl-c (KLH).
Format: Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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