Anti-Catenin, beta (CTNNB1) Recombinant Rabbit Monoclonal Antibody (clone:CTNNB1/2030R)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-12-1093-20 20 µg -

3 - 11 business days*

373.00€
 
Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the... more
Product information "Anti-Catenin, beta (CTNNB1) Recombinant Rabbit Monoclonal Antibody (clone:CTNNB1/2030R)"
Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throµghout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas. Protein function: Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E- cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22647378, PubMed:22699938, PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle. [The UniProt Consortium]
Keywords: Anti-CTNNB, Anti-CTNNB1, Anti-Beta-catenin, Anti-Catenin beta-1, Anti-Catenin, beta (CTNNB1) Recombinant Rabbit Monoclonal Antibody (Clone:CTNNB1/2030R)
Supplier: Abeomics
Supplier-Nr: 12-1093-20

Properties

Application: IHC, Protein Array
Antibody Type: Monoclonal
Clone: CTNNB1/2030R
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Recombinant full-length human CTNNB1 protein
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-Catenin, beta (CTNNB1) Recombinant Rabbit Monoclonal Antibody (clone:CTNNB1/2030R)"
Write a review
or to review a product.
Viewed