Anti-Caspase-8

Item number Size Datasheet Manual SDS Delivery time Quantity Price
600-401-AE1 100 µg - -

6 - 10 business days*

684.00€
 
Anti-Caspase-8 Antibody was affinity purified from monospecific antiserum by immunoaffinity... more
Product information "Anti-Caspase-8"
Anti-Caspase-8 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Depending on cell lines or tissues used, either full-length or other cleavage products may be observed. Protein function: Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death- inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-, -AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex. [The UniProt Consortium]
Keywords: Anti-MCH5, Anti-CASP8, EC=3.4.22.61
Supplier: Rockland Immunochemicals
Supplier-Nr: 600-401-AE1

Properties

Application: ELISA, IFM, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: 16 amino acid synthetic peptide from near the C-terminus of human Caspase-8 isoform A.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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