Anti-Caspase 7 (NT) (Caspase-7, CASP 7, CASP7, CASP-7, Apoptosis-related Cysteine Peptidase, Apoptos

Anti-Caspase 7 (NT) (Caspase-7, CASP 7, CASP7, CASP-7, Apoptosis-related Cysteine Peptidase, Apoptos
Item number Size Datasheet Manual SDS Delivery time Quantity Price
C2087-29J.100 100 µg - -

3 - 19 business days*

553.00€
 
Caspase-7, a member of the ICE/Ced-3 subfamily, is an executioner caspase which undergoes... more
Product information "Anti-Caspase 7 (NT) (Caspase-7, CASP 7, CASP7, CASP-7, Apoptosis-related Cysteine Peptidase, Apoptos"
Caspase-7, a member of the ICE/Ced-3 subfamily, is an executioner caspase which undergoes proteolytic cleavage of its precursor to form active p12 and p20 subunits. Evidence that activation of Caspase-7 occurs during cell death induced by the cytokine death receptors Fas/APO-1 and the receptor of tumor necrosis factor (TNFR-1), coupled with the fact that granzyme-B activated Caspase-7 cleaves the nuclear enzyme poly (ADP-ribose) polymerase (PARP), suggests an important role for Caspase-7 in both cytokine-mediated and Granzyme-B mediated apoptosis pathways. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 0.5ug/ml. Detects a band at ~30kD in human skeletal muscle cell lystate, Immunohistochemistry (Paraffin): 10ug/ml. Requires heat-induced antigen retrieval using sodium citrate pH 6.0., Optimal dilutions to be determined by the researcher. Positive Control: Skeletal muscle tissue, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: EC=3.4.22.60, Anti-Caspase-7 subunit p11, Anti-Caspase-7 subunit p20, Anti-Apoptotic protease Mch-3, Anti-ICE-like apoptotic protease 3
Supplier: United States Biological
Supplier-Nr: C2087-29J

Properties

Application: IHC, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: A 16aa peptide from human Caspase-7 amino-terminus.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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