• Please note that we do not deliver goods between 19.12.2019 and 03.01.2020 due to public holidays. However, we are happy to accept orders for deliveries in 2020 during this period.

Anti-Caspase-2, clone 11B4

Anti-Caspase-2, clone 11B4
Item number Size Datasheet Manual SDS Delivery time Quantity Price
AG-20T-0136-C100 100 µg - -

3 - 9 business days

Caspase-2 is a Class I caspase with a long prodomain necessary for nuclear localization. Upon... more
Product information "Anti-Caspase-2, clone 11B4"
Caspase-2 is a Class I caspase with a long prodomain necessary for nuclear localization. Upon activation of the apoptotic pathway, the procaspase is cleaved into smaller fragments. Caspase-2 is the nuclear apoptotic respondent to cellular genotoxic stress or mitotic catastrophe and is involved in the activation cascade of caspases responsible for apoptosis execution. Activation occurs upon recruitment to a complex containing a p53-induced death domain protein, PIDD. This suggests caspase-2 can be a nuclear initiator caspase with a requirement for caspase-9 and caspase-3 activation in downstream apoptotic events. In apoptotic pathways resulting from UV-induced DNA damage, processing of caspase-2 occurs downstream of mitochondrial dysfunction and of caspase-9 and caspase-3 activation, extending a possible role for caspase-2 as a parallel effector caspase.
Keywords: Anti-ICH1, Anti-CASP2, EC=
Supplier: AdipoGen Life Sciences
Supplier-Nr: AG-20T-0136-C100


Application: IP, WB
Antibody Type: Monoclonal
Clone: 11B4
Conjugate: No
Host: Rat
Reactivity: Dog, Human, Monkey, Mouse, Rat
Immunogen: Recombinant human caspase-2 (p19 subunit)
Purity: >95%
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-Caspase-2, clone 11B4"
Write a review
or to review a product.