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Anti-Caspase-2, clone 11B4

Anti-Caspase-2, clone 11B4
Item number Size Datasheet Manual SDS Delivery time Quantity Price
AG-20T-0136-C100 100 µg - -

3 - 9 business days

363.00€
 
Caspase-2 is a Class I caspase with a long prodomain necessary for nuclear localization. Upon... more
Product information "Anti-Caspase-2, clone 11B4"
Caspase-2 is a Class I caspase with a long prodomain necessary for nuclear localization. Upon activation of the apoptotic pathway, the procaspase is cleaved into smaller fragments. Caspase-2 is the nuclear apoptotic respondent to cellular genotoxic stress or mitotic catastrophe and is involved in the activation cascade of caspases responsible for apoptosis execution. Activation occurs upon recruitment to a complex containing a p53-induced death domain protein, PIDD. This suggests caspase-2 can be a nuclear initiator caspase with a requirement for caspase-9 and caspase-3 activation in downstream apoptotic events. In apoptotic pathways resulting from UV-induced DNA damage, processing of caspase-2 occurs downstream of mitochondrial dysfunction and of caspase-9 and caspase-3 activation, extending a possible role for caspase-2 as a parallel effector caspase.
Keywords: Anti-ICH1, Anti-CASP2, EC=3.4.22.55
Supplier: AdipoGen Life Sciences
Supplier-Nr: AG-20T-0136-C100

Properties

Application: IP, WB
Antibody Type: Monoclonal
Clone: 11B4
Conjugate: No
Host: Rat
Reactivity: Dog, Human, Monkey, Mouse, Rat
Immunogen: Recombinant human caspase-2 (p19 subunit)
Purity: >95%
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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