Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-64459.60 60 µl - -

7 - 16 business days*

E-AB-64459.120 120 µl - -

7 - 16 business days*

E-AB-64459.200 200 µl - -

7 - 16 business days*

The protein encoded by this gene is a component of the multiprotein assembly that is required for... more
Product information "Anti-CASC5"
The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11,15)(q23,q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed. Protein function: Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore. [The UniProt Consortium]
Keywords: Anti-CT29, Anti-CASC5, Anti-AF15q14, Anti-Blinkin, Anti-Protein CASC5, Anti-Protein D40/AF15q14, Anti-Kinetochore scaffold 1, Anti-Cancer/testis antigen 29, Anti-Kinetochore-null protein 1, Anti-Bub-linking kinetochore protein, CASC5 Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-64459


Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: Recombinant Protein of human CASC5

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