Anti-CASC3

Anti-CASC3
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-471A-T 10 µl (10 µg) -

2 - 8 business days*

164.00€
A302-471A 100 µl (100 µg) -

2 - 8 business days*

588.00€
 
Protein function: Core component of the splicing-dependent multiprotein exon junction complex... more
Product information "Anti-CASC3"
Protein function: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA- helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homopolymer. [The UniProt Consortium]
Keywords: Anti-Btz, Anti-CASC3, Anti-MLN51, Anti-MLN 51, Anti-Protein CASC3, Anti-Protein barentsz, Anti-Metastatic lymph node gene 51 protein, Anti-Cancer susceptibility candidate gene 3 protein
Supplier: Bethyl Laboratories
Supplier-Nr: A302-471A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: mouse, rat, bovine)
Immunogen: synthetic peptide. The epitope recognized by A302-471A-T maps to a region between residue 225 and 275 of human cancer susceptibility candidate 3 using the numbering given in entry NP_031385.2 (GeneID 22794).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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