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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
C1385-26A.100 | 100 µl | - | - |
3 - 19 business days* |
682.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
CARMA1 (Bimp3, CARD11) belongs to the MAGUK (membrane-associated guanylate kinase) family which... more
Product information "Anti-CARMA1 (Bimp2, CARD11)"
CARMA1 (Bimp3, CARD11) belongs to the MAGUK (membrane-associated guanylate kinase) family which typically function as molecular scaffolds in the assembly of multiprotein complexes (1, 2). MAGUK family members contain an SH3 domain, a PDZ domain and a GuK domain homologous to guanylate kinase. In addition, CARD11 contains an amino-terminal CARD domain (caspase recruitment domain). This domain plays an important role in forming interactions with a number of proteins containing CARD domains that are involved in regulating apoptosis and NF-kappa beta activation. CARD11 is predominately expressed in lymphocytes (1,2) and associates with the CARD domain of Bcl10. When overexpressed, CARD11 leads to the phosphorylation of Bcl10 and activation of NF-kappa beta (1, 2). CARD11 is constitutively associated with lipid rafts and is thought to function by recruiting Bcl10 and MALT1 and triggering the phosphorylation of IKKs (3, 4). Several studies using the genetic disruption of CARD11 or dominant-negative mutations have demonstrated that it plays a critical role in NF-kappa beta activation and lymphocyte signaling (4-7). Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000. Incubate membrane with diluted C1385-26A in 5% BSA, 1X TBS, 0.1% Tween-20 at 4ºC with gentle shaking, overnight., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-CARD11, Anti-CARMA1, Anti-Carma 1, Anti-CARD-containing MAGUK protein 1, Anti-Caspase recruitment domain-containing protein 11 |
Supplier: | United States Biological |
Supplier-Nr: | C1385-26A |
Properties
Application: | ELISA, WB |
Antibody Type: | Monoclonal |
Clone: | 7H12(1D12) |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Immunogen: | Synthetic peptide (KLH-coupled) corresponding to residues surrounding threonine 175 of CARD11. |
Format: | Supernatant |
Database Information
KEGG ID : | K07367 | Matching products |
UniProt ID : | Q9BXL7 | Matching products |
Gene ID | GeneID 84433 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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