Anti-Cardif (human), clone Adri-1

Anti-Cardif (human), clone Adri-1
%
Item number Size Datasheet Manual SDS Delivery time Quantity Discount Price
AG-20B-0004-C100 100 µg -

3 - 9 business days*

10 %
407.00€
366.30€
 
Recognizes human Cardif. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. RIG-I... more
Product information "Anti-Cardif (human), clone Adri-1"
Recognizes human Cardif. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. RIG-I (retinoic acid-inducible gene I, Ddx58) and MDA5 (melanoma differentiation-associated gene 5, also known as Ifih1 or Helicard) are proteins that sense viral replication intermediates, such as double-stranded RNA and triggers the host antiviral programs. These molecules signal the downstream activation of NF-kappaB and IFN regulatory factor (IRF) -3, which coordinately regulate the expression of type-I interferons. Cardif (also called VISA/IPS-1/MAVS) is a new CARD (caspase activation and recruitment domain)-containing adaptor protein that interacts with the CARD domain of RIG-I and MDA5, leading to the activation of NF-kappaB and IRF3. Cardif is located to the mitochondrial outer membrane. Removal of the mitochondrial-targeting domain of cardif abolishes its ability to induce IFNs. Cardif is cleaved and inactivated by NS3-4A, a serine protease from hepatitis C virus known to block interferon-beta production.
Keywords: CARD Adapter Inducing Interferon-beta, IPS-1, Interferon-beta Promoter Stimulator Protein 1, MAVS, Mitochondrial Antiviral Signaling Protein, VISA, Virus-induced Signaling Adapter
Supplier: AdipoGen Life Sciences
Supplier-Nr: AG-20B-0004

Properties

Application: ICC, IHC, IP, WB
Antibody Type: Monoclonal
Clone: Adri-1
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: Recombinant human Cardif (aa 160-450).
Format: Purified

Database Information

KEGG ID : K12648 | Matching products
UniProt ID : Q7Z434 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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