Anti-CaMKK2

Anti-CaMKK2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-R30570 100 µg - -

3 - 10 business days*

755.00€
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Calcium/calmodulin-dependent protein... more
Product information "Anti-CaMKK2"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Calcium/calmodulin-dependent protein kinase kinase 2, is an enzyme that in humans is encoded by the CaMKK2 gene. The product of this gene belongs to the serine/threonine-specific protein kinase family, and to the Ca++/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent(CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. CaMKK2 regulates production of the appetite stimulating hormone neuropeptide Y and functions as an AMPK kinase in the hypothalamus. It also has an important role in the development of hyperalgesia and tolerance to opioid analgesic drugs, through reduction in downstream signalling pathways and mu opioid receptor downregulation. Inhibition of CaMKK2 in mice reduces appetite and promotes weight loss. Protein function: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals. Seems to be involved in hippocampal activation of CREB1. May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. [The UniProt Consortium]
Keywords: Anti-CAMKK2, Anti-CAMKKB, Anti-CaMKK 2, Anti-CaM-KK 2, Anti-CaMKK beta, Anti-CaM-KK beta, EC=2.7.11.17, Anti-CaM-kinase kinase 2, Anti-CaM-kinase kinase beta, Anti-Calcium/calmodulin-dependent protein kinase kinase 2, CaMKK2 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: R30570

Properties

Application: WB, IHC (paraffin)
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: mouse, rat
Immunogen: An amino acid sequence from the middle region of CaMKK2 (KLAYNENDNTYYAMK)
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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