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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
145404.100 | 100 µg | - | - |
3 - 19 business days* |
962.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
CNN1 (calponin1 [calcium and calmodulinbinding troponin Tlike protein], also calponin basic,... more
Product information "Anti-Calponin 1 (Calponin H1, CNN1, Sm-Calp, SMCC, Calponin-1, Calcium Calmodulin-binding Troponin T"
CNN1 (calponin1 [calcium and calmodulinbinding troponin Tlike protein], also calponin basic, CaP and calponin H1) is a 3236kD cytoplasmic member of the calponin family of proteins. Although reportedly expressed in fibroblasts and endothelial cells, it actually appears to be restricted to smooth muscle and smooth musclelike cells such as myoepithalium and myofibroblasts in the adult. CNN1 interacts with Factin in a phosphorylationdependent manner. When nonphosphorylated, CNN1 blocks actomyosin ATPase activity, contributing to the stabilization of actin stress fiber bundles. Thus, CNN1 expression inhibits cell motility and the formation of podosomes. Human CNN1 is 297 amino acids (aa) in length. It contains one CH/calponin homology domain (aa30127), and three consecutive calponinlike repeats (aa164268). The repeats are suggested to mediate actin binding. There are five potential Ser/Thr phosphorylation sites. Fulllength human CNN1 shares 97% aa sequence identity with mouse CNN1. Applications: Suitable for use in ELISA, Immunohistochemistry, and Immunocytochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry: 5-15ug/ml, Immunocytochemistry: 5-15ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Supplier: | United States Biological |
Supplier-Nr: | 145404 |
Properties
Application: | ICC, IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Sheep |
Species reactivity: | human |
Format: | Affinity Purified |
Database Information
UniProt ID : | P51911 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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