Anti-Caldesmon (CAD), clone SPM168

Anti-Caldesmon (CAD), clone SPM168
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V2941-20UG 20 µg - -

3 - 10 business days

251.00€
NSJ-V2941-100UG 100 µg - -

3 - 10 business days

541.00€
 
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Recognizes a protein of 150kDa,... more
Product information "Anti-Caldesmon (CAD), clone SPM168"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Recognizes a protein of 150kDa, which is identified as the high molecular weight variant of Caldesmon. Two closely related variants of human caldesmon have been identified which are different in their electrophoretic mobility and cellular distribution. The h-caldesmon variant (120-150kDa) is predominantly expressed in smooth muscle whereas l-caldesmon (70-80kDa) is found in non- muscle tissue and cells. Neither of the two variants has been detected in skeletal muscle. This mAb recognizes only the 150kDa variant (h-caldesmon) in Western blots of human aortic media extracts and is unreactive with fibroblast extracts from cultivated human foreskin. Caldesmon is a developmentally regulated protein involved in smooth muscle and non-muscle contraction. Protein function: Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration. [The UniProt Consortium]
Keywords: Anti-CDM, Anti-CAD, Anti-CALD1, Anti-Caldesmon, Caldesmon Antibody (CAD)
Supplier: NSJ Bioreagents
Supplier-Nr: V2941-20UG

Properties

Application: FC, IF, IHC (paraffin)
Antibody Type: Monoclonal
Clone: SPM168
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Crude human uterus extract
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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