Anti-Calcineurin A, pan (Protein Phosphatase 2B,PP2B, CnA)

Anti-Calcineurin A, pan (Protein Phosphatase 2B,PP2B, CnA)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
C0114-02.100 100 µl - -

3 - 19 business days*

514.00€
 
Calcineurin, also known as protein phosphatase 2B (PP2B), is a calmodulin-dependent,... more
Product information "Anti-Calcineurin A, pan (Protein Phosphatase 2B,PP2B, CnA)"
Calcineurin, also known as protein phosphatase 2B (PP2B), is a calmodulin-dependent, calcium-activated, serine/threonine protein phosphatase composed of a catalytic subunit (calcineurin A) and a tightly bound regulatory subunit (calcineurin B) (1). Calcineurin A is highly homologous to protein phosphatases 1 and 2A. Calcineurin B, like calmodulin, contains four EF-hand, calcium-binding motifs.Calcineurin signaling has been implicated in a broad spectrum of cellular processes including cell-cycle regulation, stress response and apoptosis and is required for proper cardiovascular and skeletal muscle development (2,3). Calcineurin-mediated dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is essential for NFAT activation and nuclear translocation and early gene expression in T lymphocytes (2,3). Calcineurin is the target of the immunosuppressive drugs Cyclosporin A and FK506, both of which block the activation of quiescent T cells after T cell receptor engagement (2,3). Cyclosporin A and FK506 bind to the immunophilins, cyclophilin and FKBP respectively and the immunophilin-drug complex binds to calcineurin and blocks substrate binding. Applications: Suitable for use in Western Blot, Immunoprecipitation, Flow Cytometry and Immunofluorescence. Other applications have not been tested. Recommended Dilutions: Western Blot: 1:1000 , Immunoprecipitation: 1:50 , Immunofluorescence (IF-IC): 1:50 , Flow Cytometry: 1:25 , Optimal dilutions to be determined by the researcher. , , Storage and Stability:, May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Supplier: United States Biological
Supplier-Nr: C0114-02

Properties

Application: FC, IF, IP, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Monkey, Mouse, Rat
Immunogen: Synthetic peptide (KLH-coupled) corresponding to the carboxy-terminus of human Calcineurin A (alpha isoform).
Purity: Purified by Protein A affinity chromatography.
Format: Affinity Purified

Database Information

Handling & Safety

Storage: -20°C (-20°C Glycerol)
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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