Anti-Cadherin E (Cadherin-1, E-Cadherin, L-CAM, Epithelial Cell Adhesion Molecule, Uvomorulin, CDH1)

Anti-Cadherin E (Cadherin-1, E-Cadherin, L-CAM, Epithelial Cell Adhesion Molecule, Uvomorulin, CDH1)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
C0108-34.100 100 µg - -

3 - 19 business days*

939.00€
 
The cadherin superfamily comprises over forty proteins which are ~50-60% homologous. Cadherin... more
Product information "Anti-Cadherin E (Cadherin-1, E-Cadherin, L-CAM, Epithelial Cell Adhesion Molecule, Uvomorulin, CDH1)"
The cadherin superfamily comprises over forty proteins which are ~50-60% homologous. Cadherin expression is required for the assembly of cells into solid tissues and importantly, cadherins are expressed in a tissue speci?c fashion. Homotypic cellular interactions are promoted by homophillic interactions between the extracellular regions of like cadherin molecules on neighboring cells. Recent crystal structure analysis of an extracellular cadherin domain suggests that individual cadherin molecules cooperate to form a linear cell adhesion zipper. In addition to playing important roles in differentiation and tissue morphogenesis, cadherins also appear to play a significant role in modulating tumor invasion and metastasis. The expression of E-cadherin correlates inversely with the motile and invasive behavior of tumor cells. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry, Inhibition, Immunoprecipitation, Flow Cytometry and Immunofluorescence. Other applications not tested. Recommended Dilutions: ELISA: 1:10,000 (immobilized A431 cells) , Western Blot: 1-10ug/ml, Immunohistochemistry (Frozen or FFPE): ~10ug/ml, Inhibition of E-cadherin-dependent cell-cell contact: ~200ug/ml , Immunoprecipitation: ~5ug/IP reaction, Flow Cytometry: ~10ug/ml, Immunofluoresence: ~2-5ug/ml, Optimal dilutions to be determined by the researcher. Hybridoma: P3X63-Ag8-U1myeloma cells with spleen cells from Balb/c mice. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Supplier: United States Biological
Supplier-Nr: C0108-34

Properties

Application: ELISA, FC, IF, IHC, IP, WB
Antibody Type: Monoclonal
Clone: 3G42
Conjugate: No
Host: Mouse
Species reactivity: human
Format: Highly Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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