Anti-C1q (11S Protein)

Anti-C1q (11S Protein)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
C0010-10C.100 100 µg - -

3 - 19 business days*

784.00€
 
C1q forms together with C1r and C1s the C1 macromolecule, the first component of the classical... more
Product information "Anti-C1q (11S Protein)"
C1q forms together with C1r and C1s the C1 macromolecule, the first component of the classical complement pathway. Interaction of immune complexes with C1q induces a conformational change within the C1 complex, which results in activation of the classical pathway. C1q functions as recognition unit by binding to the heavy chain of IgG or IgM (Fc gamma and Fc micro) provided that the immunoglobulins are bound to their antigen. Furthermore, C1q can bind to apoptotic blebs, where it activates the classical complement pathway and mediates phagocytosis. As such, C1q promotes the clearance of apoptotic cells and subsequent exposure of auto antigens, thereby preventing stimulation of the immune system. , C1q is predominantly produced by macrophages but also by follicular dendritic cells, interdigitating cells and cells of the monocyte-macrophage lineage. C1q deficiency has a profound effect on host defence and clearance of immune complexes. Absence of C1q may cause autoimmunity by impairment of the clearance of apoptotic cells. Inherited C1q deficiency is also associated with the development of systemic lupus erythematosus (SLE). Applications: Suitable for use in ELISA, Western Blot, Immunofluorescence, Functional Studies and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 1:50, Immunohistochemistry (Frozen/acetone): 1:50, Optimal dilutions to be determined by the researcher. Positive Control: Spleen and kidney tissue of wild type mice, Negative Control: Spleen and kidney tissue of C1q -/- mice, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Supplier: United States Biological
Supplier-Nr: C0010-10C

Properties

Application: ELISA, IF, IHC, WB
Antibody Type: Monoclonal
Clone: JL-1
Conjugate: No
Host: Mouse
Reactivity: Human, Mouse, Rat
Immunogen: purified mouse C1q
Format: Purified

Database Information

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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