Anti-C1orf55

Anti-C1orf55
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-098A-T 10 µl (10 µg) -

3 - 9 business days*

131.00€
A302-098A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Involved in both DNA replication and cell cycle control (PubMed:27906959).... more
Product information "Anti-C1orf55"
Protein function: Involved in both DNA replication and cell cycle control (PubMed:27906959). Unprocessed SDE2 interacts with PCNA via its PIP-box. The interaction with PCNA prevents monoubiquitination of the latter thereby inhibiting translesion DNA synthesis. The binding of SDE2 to PCNA also leads to processing of SDE2 by an unidentified deubiquinating enzyme, cleaving off the N-terminal ubiquitin-like domain. The resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner (PubMed:27906959). Binding of SDE2 to PCNA is necessary to counteract damage due to ultraviolet light induced replication stress. The complete degradation of SDE2 is necessary to allow S- phase progression (PubMed:27906959). [The UniProt Consortium]
Keywords: Anti-SDE2, Anti-C1orf55, Anti-Replication stress response regulator SDE2
Supplier: Bethyl Laboratories
Supplier-Nr: A302-098A

Properties

Application: IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Rhesus Monkey, Gorilla, Chimpanzee, Crab-eating Macaque, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A302-098A-T maps to a region between residue 350 and 400 of human chromosome 1 open reading frame 55 using the numbering given in entry NP_689821.3 (GeneID 163859).
Format: Antigen Affinity Purified

Database Information

UniProt ID : Q6IQ49 | Find alternatives
Gene ID GeneID 163859 | Find alternatives

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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