Anti-Bub3 (IHC)

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
IHC-00123-T	10 µl (2500 ng)		-		2 - 8 business days*		164.00€
IHC-00123	100 µl (25 µg)		-		2 - 8 business days*		623.00€

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Protein function: Has a dual function in spindle-assembly checkpoint signaling and in promoting... more

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Product information "Anti-Bub3 (IHC)"

Protein function: Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. [The UniProt Consortium]

Keywords:	Anti-BUB3, Anti-Mitotic checkpoint protein BUB3
Supplier:	Bethyl Laboratories
Supplier-Nr:	IHC-00123

Properties

Application:	IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: mouse, rat, bovine, dog, horse, rabbit, guinea pig, swine, panda, orangutan, rhesus monkey, gorilla, tasmanian devil, white-tufted-ear marmoset, crab-eating macaque, african elephant, chinese hamster, little brown bat)
Immunogen:	synthetic peptide. The epitope recognized by IHC-00123 maps to a region between residues 275 and 325 of human BUB3 using the numbering given in Swiss-Prot entry O43684 (GeneID 9184).
Format:	Antigen Affinity Purified