Anti-BMAL1, acetylated (Lys538) (aryl hydrocarbon receptor nuclear translocator-like, Aryl hydrocarb

Anti-BMAL1, acetylated (Lys538) (aryl hydrocarbon receptor nuclear translocator-like, Aryl hydrocarb
Item number Size Datasheet Manual SDS Delivery time Quantity Price
B2179-02A.100 100 µg - -

3 - 19 business days*

666.00€
 
Brain and muscle Arnt-like protein-1 (BMAL1, also known as MOP3 or Arnt3) is a transcription... more
Product information "Anti-BMAL1, acetylated (Lys538) (aryl hydrocarbon receptor nuclear translocator-like, Aryl hydrocarb"
Brain and muscle Arnt-like protein-1 (BMAL1, also known as MOP3 or Arnt3) is a transcription factor known to regulate circadian rhythm. BMAL1 is the only component of the mammalian circadian clock whose sole deletion in a mouse model generates arrhythmicity. In addition to defects in the clock, these BMAL1 null-mice also have reproductive problems, are small in stature, age quickly and have progressive arthropathy that results in having less overall locomotor activity than wild type mice. Recent phenotyping data suggests that BMAL1 and its partner Clock also play a role in regulation of glucose homeostasis and metabolism. Finally, BMAL1, NPAS2, and PER2 have been associated with seasonal affective disorder in humans. BMAL1 transcription is circadian and reciprocally regulated by NR1D1 (Rev-erb¬alpha) and RORA, which establishes a second interlocking loop in the mammalian circadian clock. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000, Optimal dilutions to be determined by the researcher. Positive Control: Transfected HEK293/myc-BMAL1/empty vector and HEK293/myc-BMAL1/myc-CLOCK treated with Nicotinamide. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-ARNTL, Anti-bHLH-PAS protein JAP3, Anti-Member of PAS protein 3, Anti-Brain and muscle ARNT-like 1, Anti-PAS domain-containing protein 3, Anti-Basic-helix-loop-helix-PAS protein MOP3, Anti-Class E basic helix-loop-helix protein 5
Supplier: United States Biological
Supplier-Nr: B2179-02A

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Mouse
Immunogen: BMAL1 acetylated at Lysine538 (KLH). Epitope: C-Terminus.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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