Anti-BLK, NT (Tyrosine-protein Kinase Blk, B Lymphoid Tyrosine Kinase, p55-Blk) (Azide free) (PE)

Anti-BLK, NT (Tyrosine-protein Kinase Blk, B Lymphoid Tyrosine Kinase, p55-Blk) (Azide free) (PE)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
B1900-03-PE.200 200 µl - -

4 - 22 business days

696.00€
 
Protein function: Non-receptor tyrosine kinase involved in B-lymphocyte development,... more
Product information "Anti-BLK, NT (Tyrosine-protein Kinase Blk, B Lymphoid Tyrosine Kinase, p55-Blk) (Azide free) (PE)"
Protein function: Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr- 207'. Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose. [The UniProt Consortium]
Keywords: Anti-BLK, Anti-p55-Blk, EC=2.7.10.2, Anti-B lymphocyte kinase, Anti-Tyrosine-protein kinase Blk
Supplier-Nr: B1900-03-PE

Properties

Application: FLISA, IHC, WB
Antibody Type: Polyclonal
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: Synthetic peptide selected from the N-terminal region of human BLK (KLH).
Format: Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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