Anti-BCL-x

Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-60013.60 60 µl -

7 - 16 business days*

198.00€
E-AB-60013.120 120 µl -

7 - 16 business days*

317.00€
E-AB-60013.200 200 µl -

7 - 16 business days*

525.00€
 
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form... more
Product information "Anti-BCL-x"
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. Protein function: Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. [The UniProt Consortium]
Keywords: Anti-BCL2L, Anti-BCL2L1, Anti-Bcl2-L-1, Anti-Bcl-2-like protein 1, Anti-Apoptosis regulator Bcl-X, BCL-x Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-60013

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: Recombinant protein of human BCL2L1

Handling & Safety

Storage: -20°C
Shipping: 4°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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