Anti-BAF57/SMARCE1 (IHC)

Anti-BAF57/SMARCE1 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00129-T 10 µl (5+ slides) -

3 - 9 business days

125.00€
IHC-00129 100 µl (50+ slides) -

3 - 9 business days

456.00€
 
Protein function: Involved in transcriptional activation and repression of select genes by... more
Product information "Anti-BAF57/SMARCE1 (IHC)"
Protein function: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Required for the coactivation of estrogen responsive promoters by Swi/Snf complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells. [The UniProt Consortium]
Keywords: Anti-BAF57, Anti-SMARCE1, Anti-BRG1-associated factor 57, Anti-SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00129-T

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse (Expected: Horse, Rabbit, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear Marmoset, Crab-eating Macaque, Small-eared Galago, Little Brown Bat, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by IHC-00129 maps to a region between residues 360 and the C-terminus (residue 411) of human BRG1-Associated Factor 57 (SWI/SNF-Related Matrix-Associated Actin-Dependent Regulator of Chromatin E1) using the numbering given in entry
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-BAF57/SMARCE1 (IHC)"
Write a review
or to review a product.
Viewed