Anti-BACTERICIDAL PERMEABILITY INCREASING PROTEIN (BPI, CAP57)

Anti-BACTERICIDAL PERMEABILITY INCREASING PROTEIN (BPI, CAP57)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
B0003-40B.100 100 µg - -

3 - 19 business days*

784.00€
 
The antimicrobial protein BPI is a 55kD protein found in the primary (azurophilic) granules of... more
Product information "Anti-BACTERICIDAL PERMEABILITY INCREASING PROTEIN (BPI, CAP57)"
The antimicrobial protein BPI is a 55kD protein found in the primary (azurophilic) granules of human neutrophils and has also been detected on surface of neutrophils, small intestinal and oral epithelial cells. BPI is a bactericidal compound that is present in polymorphonuclear cells (PMN) and in lower levels in the specific granules of eosinophils. BPI possesses high affinity toward the lipid A region of lipopolysaccharides (LPS) that comprise the outer leaflet of the gram-negative bacterial outer membrane. Binding of BPI to the lipid A moiety of LPS exerts multiple anti-infective activities against gram-negative bacteria: 1) cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, 2) neutralization of gram-negative bacterial LPS, 3) opsonization of bacteria to enhance phagocytosis by neutrophils. Airway epithelial cells constitutively express the BPI gene and produce the BPI protein and, therefore, may be a critical determinant in the development of LPS-triggered airways disease. Inflammation induced by LPS possibly contributes to the development of rapid airflow decline, a serious and often fatal complication of hematopoietic cell transplantation. Furthermore, a 21kD bioactive recombinant fragment of BPI, rBPI21, was shown to confer a survival advantage against invasive pneumococcal disease by binding to the gram-positive bacterial pathogen, pneumolysin., , Applications: , Suitable for use in ELISA. Other applications not tested. Recommended Dilutions: ELISA: Coating or detection antibody, Optimal dilutions to be determined by the researcher., , Storage and Stability:, May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-BPI, Anti-CAP 57, Anti-Bactericidal permeability-increasing protein
Supplier: United States Biological
Supplier-Nr: B0003-40B

Properties

Application: ELISA
Antibody Type: Monoclonal
Clone: 9G129
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Human BPI.
Format: Purified

Database Information

UniProt ID : P17213 | Find alternatives
Gene ID GeneID 671 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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