Anti-Aven (Apoptosis Caspase Activation Inhibitor, Cell Death Regulator Aven, PDCD12)

Anti-Aven (Apoptosis Caspase Activation Inhibitor, Cell Death Regulator Aven, PDCD12)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A4445-11D.100 100 µl - -

3 - 19 business days*

514.00€
 
The Bcl-2 family regulates apoptosis in response to a wide range of stimuli through control of... more
Product information "Anti-Aven (Apoptosis Caspase Activation Inhibitor, Cell Death Regulator Aven, PDCD12)"
The Bcl-2 family regulates apoptosis in response to a wide range of stimuli through control of mitochondrial cytochrome c release and caspase activation. Cytosolic Apaf-1 forms a complex with caspase-9 in the presence of cytochrome c and dATP, ultimately leading to caspase-9 activation and subsequent activation of caspase-3. A large number of proteins have been found to interact with Bcl-2 and other family members that have been shown to help regulate apoptosis. Aven was identified in a yeast two-hybrid screen as a Bcl-xL interacting protein. It also interacts with other anti-apoptotic family members, including Bcl-2, but fails to interact with pro-apopotic proteins Bax and Bak. Aven inhibits apoptosis and enhances anti-apopotic activity of Bcl-xL. It interferes with association with Apaf-1 and activation of caspase-9. Aven overexpression is associated with poor prognosis in acute lymphoblastic leukemia. Applications: Suitable for use in Immunofluorescence, Flow Cytometry, ELISA and Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000, Immunofluorescence (IF-IC): 1:50, Flow Cytometry: 1:200, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Supplier: United States Biological
Supplier-Nr: A4445-11D

Properties

Application: ELISA, FC, IF, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Monkey, Mouse, Rat
Immunogen: Synthetic peptide (KLH-coupled) corresponding to residues at the carboxy terminus of Aven.
Format: Affinity Purified

Database Information

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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