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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-F53497-0.1ML | 100 µl | - | - |
3 - 10 business days* |
702.00€
|
In ascites with 0.09% sodium azide. This gene was identified based on homology to Pichia pastoris... more
Product information "Anti-ATG7, clone 29CT10.3.12"
In ascites with 0.09% sodium azide. This gene was identified based on homology to Pichia pastoris GSA7 and Saccharomyces cerevisiae APG7. In the yeast, the protein appears to be required for fusion of peroxisomal and vacuolar membranes. The protein shows homology to the ATP-binding and catalytic sites of the E1 ubiquitin activating enzymes. Protein function: E1-like activating enzyme involved in the 2 ubiquitin- like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. [The UniProt Consortium]
Keywords: | Anti-ATG7, Anti-APG7L, Anti-hAGP7, Anti-APG7-like, Anti-Autophagy-related protein 7, Anti-ATG12-activating enzyme E1 ATG7, Anti-Ubiquitin-activating enzyme E1-like protein, Anti-Ubiquitin-like modifier-activating enzyme ATG7, ATG7 Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | F53497 |
Properties
Application: | WB, ELISA |
Antibody Type: | Monoclonal |
Clone: | 29CT10.3.12 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Purified His-tagged APG7 protein was used to produced this antibody. |
Format: | Purified |
Database Information
KEGG ID : | K08337 | Matching products |
UniProt ID : | O95352 | Matching products |
Gene ID | GeneID 10533 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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