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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay26671-100 | 100 µg | - |
6 - 10 business days* |
406.00€
|
Autophagy-related 5 (ATG5), formerly known as apoptosis-specific protein (ASP), is a protein that... more
Product information "Anti-ATG5 (Clone 4D5)"
Autophagy-related 5 (ATG5), formerly known as apoptosis-specific protein (ASP), is a protein that is essential to autophagosome elongation. ATG5 is covalently conjugated to the C-terminal glycine residue of ATG12 (ATG12-ATG5) and forms a non-covalent complex with ATG16 (ATG12-ATG5-ATG16), which functions as an E3 ubiquitin ligase-like enzyme to facilitate LC3 transfer from ATG3 to phosphatidylethanolamine in canonical autophagy. ATG12-ATG5 also binds to the ATG12-ATG5-interaction region of the lysosomally localized protein TECPR1, freeing the TECPR1 pleckstrin homology domain to interact with phosphatidylinositol 3-phosphate components in the autophagosome membrane, promoting autophagosome-lysosome fusion. Polymorphisms in ATG5 have been associated with various autoimmune diseases, including lupus nephritis and Behçet's disease, gastrointestinal and colorectal cancers, as well as sporadic Parkinson's disease and childhood asthma. Cayman's ATG5 Monoclonal Antibody (Clone 4D5) can be used for ELISA, immunohistochemistry, and Western blot applications. The antibody recognizes the ATG5-ATG12 complex at approximately 56 kDa from human samples.Synonyms: APG5-like, hAPG5, Apoptosis-specific Protein, Autophagy Protein 5, Autophagy-related 5. Immunogen: Full-length human recombinant ATG5 protein. Clone Designation: 4D5. Formulation: (Request formulation change), 100 µg of Protein G-purified monoclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Mouse. Isotype: IgG1. Applications: ELISA, IHC, and WB. Cross Reactivity: (-) ATG8. UniProt Accession #: Q9H1Y0.
Keywords: | Anti-ATG5, Anti-APG5L, Anti-APG5-like, Anti-APG5-like, Anti-Autophagy protein 5, Anti-Autophagy protein 5, Anti-Apoptosis-specific protein, Anti-Apoptosis-specific protein |
Supplier: | Cayman Chemical |
Supplier-Nr: | 26671 |
Properties
Application: | ELISA, IHC, WB |
Antibody Type: | Monoclonal |
Clone: | 4D5 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Full-length human recombinant ATG5 protein |
Format: | Purified |
Database Information
KEGG ID : | K08339 | Matching products |
UniProt ID : | Q9H1Y0 | Matching products |
Gene ID | GeneID 9474 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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