Anti-Atg12, IN (Autophagy-related 12, 4931423H11Rik, A330058M13Rik, Apg12, Apg12L, APG12-like, Atg12

Anti-Atg12, IN (Autophagy-related 12, 4931423H11Rik, A330058M13Rik, Apg12, Apg12L, APG12-like, Atg12
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A2298-76M.100 100 µg - -

3 - 19 business days*

511.00€
 
Autophagy, the process of bulk degradation of cellular proteins through an... more
Product information "Anti-Atg12, IN (Autophagy-related 12, 4931423H11Rik, A330058M13Rik, Apg12, Apg12L, APG12-like, Atg12"
Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2). This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1 (3). ATG12, another member of the autophagy protein family, forms a conjugate with ATG5, this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy (4). This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells (5). ATG12 has also been shown to interact with ATG10 in human embryonic kidney cells in the presence of ATG7 (6). At least two isoforms of ATG12 are known to exist. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: Anti-Ubiquitin-like protein ATG12
Supplier: United States Biological
Supplier-Nr: A2298-76M

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide corresponding to 15aa from near the center of human ATG12 (Genbank accession No. EAW48955).
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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