Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-512A-T 20 µl (2 blots) -

3 - 9 business days*

A301-512A-M 100 µl (10 blots) -

3 - 9 business days*

A301-512A 100 µl (20 µg) -

3 - 9 business days*

Protein function: Essential component of the mitotic spindle required for normal chromosome... more
Product information "Anti-Astrin/MAP126"
Protein function: Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). [The UniProt Consortium]
Keywords: Anti-SPAG5, Anti-Astrin, Anti-MAP126, Anti-Deepest, Anti-Sperm-associated antigen 5, Anti-Mitotic spindle-associated protein p126
Supplier: Bethyl Laboratories
Supplier-Nr: A301-512A


Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Gorilla)
Immunogen: synthetic peptide. The epitope recognized by A301-512A-T maps to a region between residue 875 and 925 of human astrin (mitotic spindle associated protein p126) using the numbering given in entry NP_006452.3 (GeneID 10615).
Format: Antigen Affinity Purified

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