Anti-ARK5, CT (NUAK Family SNF1-like Kinase 1, AMPK-related Protein Kinase 5, KIAA0537, NUAK1) (Azid

Anti-ARK5, CT (NUAK Family SNF1-like Kinase 1, AMPK-related Protein Kinase 5, KIAA0537, NUAK1) (Azid
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A3570-79-PE.200 200 µl - -

4 - 22 business days

696.00€
 
Protein function: Serine/threonine-protein kinase involved in various processes such as cell... more
Product information "Anti-ARK5, CT (NUAK Family SNF1-like Kinase 1, AMPK-related Protein Kinase 5, KIAA0537, NUAK1) (Azid"
Protein function: Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser- 392' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. [The UniProt Consortium]
Keywords: Anti-ARK5, Anti-NUAK1, EC=2.7.11.1, Anti-Omphalocele kinase 1, Anti-AMPK-related protein kinase 5, Anti-NUAK family SNF1-like kinase 1
Supplier-Nr: A3570-79-PE

Properties

Application: FLISA, IHC, WB
Antibody Type: Polyclonal
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: Synthetic peptide selected from the C-terminal region of human ARK5 (KLH).
Format: Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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