Anti-ARHGEF2

Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-14606.20 20 µl - -

7 - 16 business days*

63.00€
E-AB-14606.60 60 µl - -

7 - 16 business days*

117.00€
E-AB-14606.120 120 µl - -

7 - 16 business days*

208.00€
E-AB-14606.200 200 µl - -

7 - 16 business days*

363.00€
 
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by... more
Product information "Anti-ARHGEF2"
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified. Protein function: Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF- alpha secretion in macrophage upon stimulation by bacterial peptidoglycans, acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability. Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons. [The UniProt Consortium]
Keywords: Anti-GEF-H1, Anti-ARHGEF2, Anti-KIAA0651, Anti-Microtubule-regulated Rho-GEF, Anti-Guanine nucleotide exchange factor H1, Anti-Proliferating cell nucleolar antigen p40, Anti-Rho guanine nucleotide exchange factor 2, ARHGEF2 Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-14606

Properties

Application: IHC, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human ARHGEF2
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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