Anti-amyloid beta peptide, clone NT 4A2, N-terminal

Anti-amyloid beta peptide, clone NT 4A2, N-terminal
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ARG10183.100 100 µg - -

6 - 14 business days*

624.00€
 
Protein function: Functions as a cell surface receptor and performs physiological functions on... more
Product information "Anti-amyloid beta peptide, clone NT 4A2, N-terminal"
Protein function: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER- dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. [The UniProt Consortium]
Keywords: Anti-A4, Anti-APP
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG10183

Properties

Application: ELISA
Antibody Type: Monoclonal
Clone: NT 4A2
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: Full length human beta amyloid peptide 42
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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