Anti-alpha TAP (human)

Anti-alpha TAP (human)
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Item number Size Datasheet Manual SDS Delivery time Quantity Price
200-401-102 100 µg - -

3 - 9 business days*

506.00€
 
Protein function: Involved in the transport of antigens from the cytoplasm to the endoplasmic... more
Product information "Anti-alpha TAP (human)"
Protein function: Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules. [The UniProt Consortium]
Keywords: Anti-TAP1, Anti-APT1, Anti-PSF-1, Anti-ABCB2, Anti-Peptide supply factor 1, Anti-Peptide transporter TAP1, Anti-Peptide transporter PSF1, Anti-Antigen peptide transporter 1, Anti-Really interesting new gene 4 protein
Supplier: Rockland Immunochemicals
Supplier-Nr: 200-401-102

Properties

Application: WB, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: synthetic peptide corresponding to the C-terminus of human transporter associated protein (TAP I)
Format: IgG

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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