Anti-Akirin2, IN1 (C6orf166, chromosome 6 open reading frame 166, dJ486L4.2, FBI1, FLJ10342, Protein

Anti-Akirin2, IN1 (C6orf166, chromosome 6 open reading frame 166, dJ486L4.2, FBI1, FLJ10342, Protein
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A1105-81.100 100 µg - -

3 - 19 business days*

511.00€
 
The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the... more
Product information "Anti-Akirin2, IN1 (C6orf166, chromosome 6 open reading frame 166, dJ486L4.2, FBI1, FLJ10342, Protein"
The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-kappaB-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kappaB pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death. Applications: Suitable for use in Elisa and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml, Optimal dilutions to be determined by the researcher. Positive Control: Mouse Brain Tissue Lysate, Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: Anti-Akirin-2
Supplier: United States Biological
Supplier-Nr: A1105-81

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: Synthetic peptide corresponding to 15aa from near the center of the human Akirin2.
Format: Affinity Purified

Database Information

UniProt ID : Q53H80 | Find alternatives
Gene ID GeneID 55122 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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